Familial thyroid cancer

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Familial Papillary Thyroid Cancer

In the familial form of papillary thyroid cancer (PTC), two or more members of the same family have to be affected with PTC. Prevalence is around 5% of all PTC. We performed a clinical analysis in 79 relatives of 16 patients of 7 unrelated kindred with the diagnosis of familial papillary thyroid carcinoma (FPTC). The results were compared with a control group. Thyroid palpation and TSH and TPO-...

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Familial Nonmedullary Thyroid Cancer

FAMILIAL NONMEDULLARY THYROID CANCER (Abstract): Follicular cell-derived thyroid cancer which represents 90-95% of all thyroid malignancies may occur in at least 5% of cases as familial disease. Familial nonmedullary thyroid cancer (FNMTC) is defined as the existence of two or more first degree relatives affected within a family. FNMTC may occur in two situations: pure FNMTC in which FNMTC is t...

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Controversies in familial thyroid cancer 2014.

Thyroid cancer is the sixth most common cancer in women, and the majority of patients with thyroid cancer has sporadic disease. However, about 25% of patients with medullary thyroid cancer and 5% with papillary thyroid cancer have familial tumors. Currently, there are numerous controversies regarding the mode of inheritance, tumor behavior, extent of surgical resection for optimal results, coex...

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Familial Adenomatous Polyposis-Associated Papillary Thyroid Cancer.

Papillary thyroid carcinoma (PTC) associated with familial adenomatous polyposis (FAP) is rare. It is usually associated with the cribriform-morular variant of PTC, with unusual patterns on detailed histology examination. This variant is known to have a good prognosis. Papillary thyroid carcinoma associated with FAP commonly occurs in females in their 30s and rarely in the elderly. We report a ...

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Familial nonmedullary thyroid carcinoma.

BACKGROUND Nonmedullary thyroid carcinomas (NMTCs) originate from the thyroid epithelial cells and, until recently, were thought to arise sporadically without an inherited genetic predisposition. However, evidence of a familial predisposition to NMTC is accumulating. METHODS This review addresses the strengths, weaknesses, and clinical implications of the observations indicating an inherited ...

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ژورنال

عنوان ژورنال: Cancer

سال: 1962

ISSN: 0008-543X,1097-0142

DOI: 10.1002/1097-0142(196203/04)15:2<241::aid-cncr2820150205>3.0.co;2-n